Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The promise of paediatric genomics depends on proactively addressing complex ethical and equity issues with sustained community engagement. Hernandez et al. advocate for the integration of ELSI scholars into paediatric genomic study teams to catalyse timely discovery in genomics.
Gene therapy for congenital deafness has made a breakthrough in recent clinical trials. However, more work is needed to develop successful treatments for hereditary hearing loss, as the authors argue in this Comment.
In this Tools of the Trade article, Yan Hu explains the development and application of PRINT and seq2PRINT, computational tools that together use single-cell ATAC-seq data to predict protein binding dynamics at detailed cellular resolution.
In this Tools of the Trade article, Arafath Najumudeen and Johan Vande Voorde showcase the potential of mass spectrometry imaging for spatial metabolomics by highlighting its application in cancer, revealing metabolic differences between cell populations in the tumour microenvironment.
In this Journal Club, Mariana Boroni recalls a 2012 study by Gerlinger et al. that revealed the complex and branched evolution of cancer and challenged the prevailing view of linear tumour progression.
Circular RNAs have gained attention for their stability, immunological advantages and regulatory functions, making them a promising modality in multiple therapies. This Review discusses the therapeutic prospects of circular RNA-based approaches and the emerging role of circular RNAs as biomarkers in disease.
Kojima, Hoppe and Giraldez provide this cross-species Review of the cytoplasmic and nuclear remodelling that occurs after fertilization to permit zygotic genome activation (ZGA) and enable the shift from maternal to zygotic control of development (the maternal-to-zygotic transition).
Genomic and pangenomic data are yielding insights into the evolution of plant pattern recognition receptors (PRRs) and their molecular triggers. Recent advances in in silico and in vivo methods, alongside protein structure prediction, are helping to harness these insights for PRR engineering, offering sustainable solutions for broad-spectrum plant disease resistance.
Biomolecular condensates are membraneless cellular compartments that concentrate molecules such as proteins and nucleic acids. In this Review, the authors discuss how complementation experiments, a classic genetics approach, have provided valuable insights into the functions of biomolecular condensates.
