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Barkley and colleagues conducted single-cell RNA sequencing of almost 20,000 malignant cells and identified cancer cell states that are both common and different across tumour types, and revealed how these states interact with the tumour microenvironment.
In this Tools of the Trade article, Anne C. Rios describes the development of multispectral large-scale single-cell resolution three-dimensional (mLSR-3D) imaging and the analytical pipeline, segmentation analysis by parallelization of 3D datasets (STAPL-3D), which enables the extraction of hundreds of molecular, spatial and volumetric features from millions of cells imaged in 3D, revealing details of the structural organization of human tumours.
Venkataramani et al. used longitudinal intravital two-photon imaging to track migrating glioblastoma cells in vivo, and identified a seemingly unconnected cell subpopulation that was responsible for colonization of the brain by mimicking neuronal mechanisms of movement.
Chen et al. have developed a preclinical platform that enables the reprogramming of locoregional macrophages and microglia in situ with CD133-directed chimeric antigen receptors, which leads to the phagocytosis and removal of residual glioma stem cells after tumour debulking.
In this Viewpoint article, we asked four scientists working in the field of cancer nanomedicine to provide their opinions on how we can truly fulfil the great promise of nanotechnologies for the detection, diagnosis and treatment of patients with cancer.
This review gives an overview of natural killer (NK) cell-based immunotherapies. The authors describe the various engineering strategies used to increase NK cell cytotoxicity and persistence, as well as the current challenges and opportunities for the future design of next-generation NK cell therapies.
Environmental exposure to aristolochic acid-containing plant material and its use in traditional medicines have been linked to a wide range of cancers. In this Review, Das et al. describe the evidence for aristolochic acid as a potent carcinogen and explore the impact of public health measures on preventing aristolochic acid-linked cancers and nephropathy, with a call to action for the implementation of further preventative measures.
Malignant cells show uninhibited proliferation and cellular plasticity, features also reminiscent of embryogenesis. In this Perspective, Sharma and colleagues present their oncofetal ecosystem concept, discuss evidence of oncofetal reprogramming in malignant and non-malignant cells, and debate the therapeutic relevance of these findings.
