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FEEDING BEHAVIOR

Silencing gut CCK cells alters gut reaction to sugar

Nature Neuroscience volume 25, pages 136–138 (2022)Cite this article

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The duodenum distinguishes between sugar and sweeteners, but the cells involved in this process remain elusive. Buchanan and colleagues engineered a flexible optic fiber for optogenetic manipulation of gut cells in mice. Silencing duodenal CCK cells reduced the preference for sugar over sweetener intake. Gut optogenetics may elucidate how the gut–brain axis regulates feeding and glucose homeostasis.

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Fig. 1: Proposed use of gut optogenetics to dissect the regulation of feeding and glucose homeostasis by the gut–brain axis.

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Acknowledgements

J.T.Y.Y. is supported by the Canadian Institutes for Health Research (CIHR; PJT-378765), the Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-06657), and the Canada Foundation for Innovation John R. Evans Leaders Fund (37267), is a Tier 2 Canada Research Chair in Brain Regulation of Metabolism at the University of Alberta, and was supported by a Diabetes Canada Scholar Award (SC-5-16-5060-JY). F.A.D. is funded by the National Institutes of Health (NIH-1R01DK121804) and United States Department of Agriculture (USDA)–National Institute of Food and Agriculture (NIFA) (2019-67017-29252). T.K.T.L. is supported by a CIHR Foundation Grant (FDN-143204), holds the John Kitson McIvor (1915–1942) Endowed Chair in Diabetes Research, and is a Tier 1 Canada Research Chair in Diabetes and Obesity at the Toronto General Hospital Research Institute and the University of Toronto.

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Authors and Affiliations

  1. Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

    Jessica T. Y. Yue

  2. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA

    Frank A. Duca

  3. BIO 5 Institute, University of Arizona, Tucson, AZ, USA

    Frank A. Duca

  4. Toronto General Hospital Research Institute, UHN, Toronto, Ontario, Canada

    Tony K. T. Lam

  5. Department of Physiology, University of Toronto, Toronto, Ontario, Canada

    Tony K. T. Lam

  6. Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    Tony K. T. Lam

  7. Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

    Tony K. T. Lam

Authors
  1. Jessica T. Y. Yue
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  2. Frank A. Duca
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  3. Tony K. T. Lam
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Corresponding authors

Correspondence to Jessica T. Y. Yue or Tony K. T. Lam.

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Yue, J.T.Y., Duca, F.A. & Lam, T.K.T. Silencing gut CCK cells alters gut reaction to sugar. Nat Neurosci 25, 136–138 (2022). https://doi.org/10.1038/s41593-021-00998-z

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