An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome.
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Gaudieri, S., Lucas, M. Innate and adaptive immunity shape circulating HCV strains. Nat Genet 49, 657–658 (2017). https://doi.org/10.1038/ng.3856
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DOI: https://doi.org/10.1038/ng.3856