Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BLADDER CANCER

Exploring the molecular basis of sexual dimorphism in bladder cancer

Bladder cancer outcomes differ between men and women. Elucidating this sexual dimorphism, genomic analyses found differing molecular subtype distributions and androgen response activities in muscle-invasive bladder cancer in men and women. Together with knowledge of cancer driver genes, biomarkers and clinical characteristics, these findings will hopefully lead to sex-based personalized research and management of bladder cancer.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Najari, B. B. et al. Sex disparities in cancer mortality: the risks of being a man in the United States. J. Urol. 189, 1470–1474 (2013).

    Article  Google Scholar 

  2. Mori, K. et al. Differential effect of sex on outcomes after radical surgery for upper tract and bladder urothelial carcinoma: a systematic review and meta-analysis. J. Urol. https://doi.org/10.1097/JU.0000000000000788 (2020).

    Article  PubMed  Google Scholar 

  3. Dobruch, J. et al. Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes. Eur. Urol. 69, 300–310 (2016).

    Article  Google Scholar 

  4. Yuan, Y. et al. Comprehensive characterization of molecular differences in cancer between male and female patients. Cancer Cell 29, 711–722 (2016).

    Article  CAS  Google Scholar 

  5. Kamoun, A. et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur. Urol. 77, 420–433 (2019).

    Article  Google Scholar 

  6. de Jong, J. J. et al. Distribution of molecular subtypes in muscle-invasive bladder cancer is driven by sex-specific differences. Eur. Urol. Oncol. https://doi.org/10.1016/j.euo.2020.02.010 (2020).

    Article  PubMed  Google Scholar 

  7. Trilla-Fuertes, L. et al. Biological molecular layer classification of muscle-invasive bladder cancer opens new treatment opportunities. BMC Cancer 19, 636 (2019).

    Article  Google Scholar 

  8. Jahrreiss, V., Pradere, B., Laukhtina, E., Mori, K. & Shariat, S. F. Catalog of exogenous risk factors for bladder carcinogenesis. Curr. Opin. Urol. 30, 449–456 (2020).

    Article  Google Scholar 

  9. Krimphove, M. J. et al. Sex-specific differences in the quality of treatment of muscle-invasive bladder cancer do not explain the overall survival discrepancy. Eur. Urol. Focus https://doi.org/10.1016/j.euf.2019.06.001 (2019).

    Article  PubMed  Google Scholar 

  10. Lucca, I., Klatte, T., Fajkovic, H., de Martino, M. & Shariat, S. F. Gender differences in incidence and outcomes of urothelial and kidney cancer. Nat. Rev. Urol. 12, 653 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahrokh F. Shariat.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pradere, B., Shariat, S.F. Exploring the molecular basis of sexual dimorphism in bladder cancer. Nat Rev Urol 17, 487–488 (2020). https://doi.org/10.1038/s41585-020-0339-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41585-020-0339-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing