Astrocytes are emerging as causal or modulating factors in diverse neurological disorders. Two papers published in Nature Neuroscience in 2007 revealed astrocytes as causally contributing to motor neuron loss in amyotrophic lateral sclerosis, thereby challenging the longstanding neuron-centric view of neurodegenerative disease.
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References
Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T. & Eggan, K. Nat. Neurosci. 10, 608–614 (2007).
Nagai, M. et al. Nat. Neurosci. 10, 615–622 (2007).
Rosen, D. R. et al. Nature 362, 59–62 (1993).
Tong, J. et al. EMBO J. 32, 1917–1926 (2013).
Kia, A., McAvoy, K., Krishnamurthy, K., Trotti, D. & Pasinelli, P. Glia 66, 1016–1033 (2018).
Liddelow, S. A. et al. Nature 541, 481–487 (2017).
Clarke, L. E. et al. Proc. Natl. Acad. Sci. USA 115, E1896–E1905 (2018).
Boisvert, M. M., Erikson, G. A., Shokhirev, M. N. & Allen, N. J. Cell Rep. 22, 269–285 (2018).
Gibson, E. M. et al. Cell 176, 43–55.e13 (2019).
Bush, T. G. et al. Neuron 23, 297–308 (1999).
Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J. & Kuncl, R. W. Ann. Neurol. 38, 73–84 (1995).
Phatnani, H. P. et al. Proc. Natl. Acad. Sci. USA 110, E756–E765 (2013).
Zamanian, J. L. et al. J. Neurosci. 32, 6391–6410 (2012).
Anderson, M. A. et al. Nature 532, 195–200 (2016).
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Liddelow, S.A., Sofroniew, M.V. Astrocytes usurp neurons as a disease focus. Nat Neurosci 22, 512–513 (2019). https://doi.org/10.1038/s41593-019-0367-6
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DOI: https://doi.org/10.1038/s41593-019-0367-6
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