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The reconstructed natural history of type 1 diabetes mellitus

Nature Reviews Endocrinology volume 15, pages 256–257 (2019)Cite this article

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The causes of type 1 diabetes mellitus (T1DM) are unclear; however, a general consensus exists that T1DM is a T cell-mediated autoimmune disease characterized by the selective destruction of insulin-secreting β-cells. Now, two imaging mass cytometry studies of human pancreatic tissue illuminate new biology in the pathogenesis of T1DM.

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References

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Authors and Affiliations

  1. Unit of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy

    Paolo Pozzilli

  2. Centre of Immunobiology, Blizard Institute, Queen Mary, University of London, London, UK

    Paolo Pozzilli

  3. Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, “Sapienza” University of Rome, Rome, Italy

    Alberto Signore

Authors
  1. Paolo Pozzilli
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  2. Alberto Signore
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The authors contributed equally to all aspects of the article.

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Correspondence to Paolo Pozzilli.

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The authors declare no competing interests.

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Pozzilli, P., Signore, A. The reconstructed natural history of type 1 diabetes mellitus. Nat Rev Endocrinol 15, 256–257 (2019). https://doi.org/10.1038/s41574-019-0192-8

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