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Cardiovascular diseases

Cellular origin of human cardiac macrophage populations

The human heart contains two macrophage populations with distinct self-maintenance and inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling and systolic function in patients with heart failure.

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Fig. 1: The human heart contains two populations of macrophages with different origins and functions.

References

  1. Ginhoux, F. & Guilliams, M. Immunity 44, 439–449 (2016).

    Article  CAS  Google Scholar 

  2. Epelman, S. et al. Immunity 40, 91–104 (2014).

    Article  CAS  Google Scholar 

  3. Molawi, K. et al. J. Exp. Med. 211, 2151–2158 (2014).

    Article  CAS  Google Scholar 

  4. Van der Borght, K. & Lambrecht, B. N. Cell. Immunol. https://doi.org/10.1016/j.cellimm.2018.03.011 (2018).

    Article  CAS  Google Scholar 

  5. Sawai, C. M. et al. Immunity 45, 597–609 (2016).

    Article  CAS  Google Scholar 

  6. Bajpai, G. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0059-x (2018).

    Article  CAS  Google Scholar 

  7. McGovern, N. et al. Immunity 41, 465–477 (2014).

    Article  CAS  Google Scholar 

  8. Nayak, D. K. et al. Am. J. Transplant. 16, 2300–2311 (2016).

    Article  CAS  Google Scholar 

  9. Guilliams, M. & Scott, C. L. Nat. Rev. Immunol. 17, 451–460 (2017).

    Article  CAS  Google Scholar 

  10. Bonnardel, J. & Guilliams, M. Curr. Opin. Immunol. 50, 64–74 (2018).

    Article  CAS  Google Scholar 

  11. Rozenblatt-Rosen, O., Stubbington, M. J. T., Regev, A. & Teichmann, S. A. Nature 550, 451–453 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Martin Guilliams.

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Svedberg, F.R., Guilliams, M. Cellular origin of human cardiac macrophage populations. Nat Med 24, 1091–1092 (2018). https://doi.org/10.1038/s41591-018-0143-2

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