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Volume 17 Issue 5, May 2021

COVID-19 vaccines, inspired by the Comment on p291

Cover design: Lara Crow

Comment

  • Patients with kidney diseases should be prioritized for COVID-19 vaccination and the available data suggest that replication-defective viral-vectored vaccines and mRNA vaccines are safe to use. As vaccine responses are likely to be lower in patients with kidney diseases than in the general population, highly potent vaccines should be preferred.

    • Martin Windpessl
    • Annette Bruchfeld
    • Andreas Kronbichler
    Comment

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  • The incidence of kidney diseases from communicable and non-communicable causes is expected to increase globally — especially in low and middle-income countries — as a consequence of global warming. As this increase could lead to overburdening of health-care systems, action is crucial to minimize the negative impacts of climate change on kidney health.

    • Matthew A. Borg
    • Peng Bi
    Comment
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Research Highlights

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Reviews

  • Mitochondrial dysfunction has roles in acute kidney injury, chronic kidney disease and abnormal kidney repair. Here, the authors discuss the role of mitochondrial quality control mechanisms in kidney injury and repair and highlight their potential as therapeutic targets.

    • Chengyuan Tang
    • Juan Cai
    • Zheng Dong
    Review Article
  • Multiple pathophysiological disturbances contribute to the onset and progression of diabetic kidney disease (DKD). This Review describes these pathogenic processes and discusses the ability of sodium–glucose co-transporter 2 (SGLT2) inhibitors to correct or improve many of these processes, which are likely to underlie the ability of these agents to slow progression of established diabetic kidney disease.

    • Ralph A. DeFronzo
    • W. Brian Reeves
    • Alaa S. Awad
    Review Article
  • In this Review, the authors examine the physiological heterogeneity of different kidney compartments and consider how the local oxygen supply and the capacity for metabolic adaptation of different nephron segments might influence their response to changes in oxygen availability and their susceptibility to injury.

    • Holger Scholz
    • Felix J. Boivin
    • Pontus B. Persson
    Review Article
  • In this Review, the authors discuss the renal mechanism of salt-sensitive hypertension induced by malnutrition during pregnancy, obesity in adult life and ageing. They also describe the epigenetic mechanisms that potentially contribute to the development of salt-sensitive hypertension in these settings.

    • Wakako Kawarazaki
    • Toshiro Fujita

    Series:

    Review Article
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