Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

The new liver epidemic

NASH has replaced hepatitis C as the most important nonalcoholic liver disease. Biotech and pharma are racing to tap into this enormous market.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Perry, R. J., Samuel, V. T., Petersen, K. F. & Shulman, G. I. Nature 510, 84–91 (2014).

    Article  CAS  Google Scholar 

  2. Sanyal, A. J. et al. N. Engl. J. Med. 362, 1675–1685 (2010).

    Article  CAS  Google Scholar 

  3. Huang, M. A. et al. Am. J. Gastroenterol. 100, 1072–1081 (2005).

    Article  Google Scholar 

  4. Promrat, K. et al. Hepatology 51, 121–129 (2010).

    Article  CAS  Google Scholar 

  5. Parks, D. J. et al. Science 284, 1365–1368 (1999).

    Article  CAS  Google Scholar 

  6. Holt, J. A. et al. Genes Dev. 17, 1581–1591 (2003).

    Article  CAS  Google Scholar 

  7. Neuschwander-Tetri, B. A. et al. Lancet 385, 956–965 (2015).

    Article  CAS  Google Scholar 

  8. Loomba, R. et al. Hepatology 67, 549–559 (2018).

    Article  CAS  Google Scholar 

  9. Pawlak, M. et al. Hepatology 60, 1593–1606 (2014).

    Article  CAS  Google Scholar 

  10. Ratziu, V. et al. Gastroenterology 150, 1147–1159 (2016).

    Article  CAS  Google Scholar 

  11. Friedman, S. L. et al. Hepatology 67, 1754–1767 (2018).

    Article  CAS  Google Scholar 

  12. Armstrong, M. J. et al. Lancet 387, 679–690 (2016).

    Article  CAS  Google Scholar 

  13. Patel, K. et al. Hepatology 68 (Suppl. 1), 438A, abstract 736 (2018).

  14. Luo, J. et al. Sci. Transl. Med. 6, 247ra100 (2014).

    Article  Google Scholar 

  15. Harrison, S. A. et al. Lancet 391, 1174–1185 (2018).

    Article  CAS  Google Scholar 

  16. Romeo, S. et al. Nat. Genet. 40, 1461–1465 (2008).

    Article  CAS  Google Scholar 

  17. Yuan, X. et al. Am. J. Hum. Genet. 83, 520–528 (2008).

    Article  CAS  Google Scholar 

  18. Linden D. et al. Hepatology 68 (Supp. 1), 440A, abstract 740 (2018).

  19. Kozlitina, J. et al. Nat. Genet. 46, 352–356 (2014).

    Article  CAS  Google Scholar 

  20. Abul-Husn, N. S. et al. N. Engl. J. Med. 378, 1096–1106 (2018).

    Article  CAS  Google Scholar 

  21. Ma, Y. et al. Hepatology https://doi.org/10.1002/hep.30350 (2018).

  22. About, F., Abel, L. & Cobat, A. N. Engl. J. Med. 379, 1875–1876 (2018).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Garber, K. The new liver epidemic. Nat Biotechnol 37, 209–214 (2019). https://doi.org/10.1038/s41587-019-0047-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-019-0047-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing