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Prospects for plant-derived antibacterials

Can weakly active phytochemicals be combined synergistically to produce new antibacterial treatments?

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Frank R. Stermitz, Colorado State University

References

  1. Dixon, R.A. Nature 411, 843–847 (2001).

    Article  CAS  Google Scholar 

  2. Han, G.-Y. et al. Acta Chimi. Sin. [in Chinese] 39, 433–437 (1981).

    CAS  Google Scholar 

  3. Gibbons, S. Nat. Prod. Rep. 21, 263–277 (2004).

    Article  CAS  Google Scholar 

  4. Hammerschmidt, R. Annu. Rev. Phytopathol. 37, 285–306 (1999).

    Article  CAS  Google Scholar 

  5. Bryskier, A., ed. Antimicrobial Agents: Antibacterials and Antifungals (ASM Press, Washington DC, 2005).

    Book  Google Scholar 

  6. Amin, A.H., Subbaiah, T.V. & Abbasi, K.M. Can. J. Microbiol. 15, 1067–1076 (1969).

    Article  CAS  Google Scholar 

  7. Severina, I.I., Muntyan, M.S., Lewis, K. & Skulachev, V.P. IUBMB Life 52, 321–324 (2001).

    Article  CAS  Google Scholar 

  8. Hsieh, P.C., Siegel, S.A., Rogers, B., Davis, D. & Lewis, K. Proc. Natl. Acad. Sci. USA 95, 6602–6606 (1998).

    Article  CAS  Google Scholar 

  9. Lewis, K. J. Mol. Microbiol. Biotechnol. 3, 247–254 (2001).

    CAS  PubMed  Google Scholar 

  10. Stermitz, F.R., Lorenz, P., Tawara, J.N., Zenewicz, L. & Lewis, K. Proc. Natl. Acad. Sci. USA 97, 1433–1437 (2000).

    Article  CAS  Google Scholar 

  11. Tegos, G., Stermitz, F.R., Lomovskaya, O. & Lewis, K. Antimicrob. Agents Chemother. 46, 3133–3141 (2002).

    Article  CAS  Google Scholar 

  12. Lomovskaya, O. & Lewis, K. Proc. Natl. Acad. Sci. USA 89, 8938–8942 (1992).

    Article  CAS  Google Scholar 

  13. Nikaido, H. Curr. Opin. Microbiol. 1, 516–523 (1998).

    Article  CAS  Google Scholar 

  14. Bauer, G., Berens, C., Projan, S.J. & Hillen, W. J. Antimicrob. Chemother. 53, 592–599 (2004).

    Article  CAS  Google Scholar 

  15. Pankey, G.A. J. Antimicrob. Chemother. 56, 470–480 (2005).

    Article  CAS  Google Scholar 

  16. Adonizio, A.L., Downum, K., Bennett, B.C. & Mathee, K. J. Ethnopharmacol. 105, 427–435 (2006).

    Article  Google Scholar 

  17. Bauer, W.D. & Mathesius, U. Curr. Opin. Plant Biol. 7, 429–433 (2004).

    Article  CAS  Google Scholar 

  18. Teplitski, M., Robinson, J.B. & Bauer, W.D. Mol. Plant Microbe Interact. 13, 637–648 (2000).

    Article  CAS  Google Scholar 

  19. Hung, D.T., Shakhnovich, E.A., Pierson, E. & Mekalanos, J.J. Science 310, 670–674 (2005).

    Article  CAS  Google Scholar 

  20. Silver, L. IDrugs 9, 394–397 (2006).

    PubMed  Google Scholar 

  21. Stermitz, F.R., Scriven, L.N., Tegos, G. & Lewis, K. Planta Med. 68, 1140–1141 (2002).

    Article  CAS  Google Scholar 

  22. Morel, C., Stermitz, F.R., Tegos, G. & Lewis, K. J. Agric. Food Chem. 51, 5677–5679 (2003).

    Article  CAS  Google Scholar 

  23. Stermitz, F.R. et al. Bioorg. Med. Chem. Lett. 13, 1915–1918 (2003).

    Article  CAS  Google Scholar 

  24. Belofsky, G., Percivill, D., Lewis, K., Tegos, G.P. & Ekart, J. J. Nat. Prod. 67, 481–484 (2004).

    Article  CAS  Google Scholar 

  25. Belofsky, G. et al. J. Nat. Prod. 69, 261–264 (2006).

    Article  CAS  Google Scholar 

  26. Lomovskaya, O. et al. Antimicrob. Agents Chemother. 45, 105–116 (2001).

    Article  CAS  Google Scholar 

  27. Ball, A.R. et al. ACS Chem. Biol. 1, 594–600 (2006).

    Article  CAS  Google Scholar 

  28. Moy, T.I. et al. Proc. Natl. Acad. Sci. USA 103, 10414–10419 (2006).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Critical comments and advice of S. Gibbons, L. Silver, J. Clancy, and O. Lomovskaya are greatly appreciated. Work described in this paper was supported by US National Institutes of Health grants AI059483 to K.L. and AI064332 to F.M.A.

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Lewis, K., Ausubel, F. Prospects for plant-derived antibacterials. Nat Biotechnol 24, 1504–1507 (2006). https://doi.org/10.1038/nbt1206-1504

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