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Research funders are uniquely placed to develop and promote collaborations between multiple partners, including industry, in a positive and ethical way. This Comment calls for funders to take action to ensure that discoveries progress from the lab to patients with cancer.
Wieland et al. report that the tumour microenvironment of human papillomavirus (HPV)-positive head and neck squamous cell carcinomas contains HPV-specific B cells that actively secrete HPV-specific antibodies.
Banh et al. show that peripheral axons of sensory nerves release serine into the tumour microenvironment, which can support the growth of extracellular serine-dependent pancreatic ductal adenocarcinoma by promoting mRNA translation.
The hostile microenvironment of the tumour can disrupt endoplasmic reticulum (ER) homeostasis in cancer cells and infiltrating immune cells to result in a state of ER stress. This Review discusses how ER stress can influence not only the pro-tumoural features of cancer cells but also reprogramme the function of innate and adaptive immune cells, creating vulnerabilities that could be targeted by emerging therapeutic strategies.
This Review discusses the diverse facets of cancer biology that are shaped by aneuploidy and highlights the distinct roles of aneuploidy as both a tumour promoter and an anticancer vulnerability.
This Review examines recent developments in the molecular and translational aspects of bladder cancer biology and discusses their current or potential future clinical applications in the management of bladder cancer.
This Review highlights the different genetic pathways impacted by germline mutations that can lead to the development of familial and sporadic haematological malignancies, with a particular focus on recent advances in acute lymphoblastic leukaemia, acute myeloid leukaemia and myelodysplastic syndromes.
