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Black people have the highest cancer rates in the USA owing to systemic racism — biased systems that put pressure on Black lives every day. STEM scholars have a responsibility to reduce the historical trauma associated with systemic racism. This also means challenging systemic racism within STEM fields.
Torrino et al. report that extracellular matrix stiffening stabilizes microtubules by glutaminolysis-dependent microtubule glutamylation, thereby promoting breast cancer progression.
This Review provides an update of interleukins in tumour biology, covering the milestones of the latest discoveries of interleukin-related mechanisms in cancer, together with their application in clinical practice. It includes an overview of current clinical trials and breakthrough preclinical concepts.
Despite the vast size of the non-coding genome, driver mutations in this space appear to be relatively infrequent. This Review highlights recent notable discoveries and challenges in the field of non-coding driver mutations, with a focus on somatic point mutations and indels.
This Review examines the tissue-specific metabolism and associated therapeutic vulnerabilities of mutant KRAS-driven tumours, providing a comparative discussion of intrinsic metabolism, co-occurring mutations and metabolic interactions in the microenvironment in colorectal, lung and pancreatic cancer.
This Perspective discusses the signalling programmes and biological factors that simultaneously induce cancer stem cells and reprogramme the immune response to facilitate tumour immune evasion. It also highlights therapeutic opportunities for simultaneous targeting of the cancer stem cell niche and immunosurveillance.
