npj Aging

Pairwise analysis of RNA sequencing data

Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns

Hyeon-Mu Cho
Se-Hee Choe
Jae-Won Huh

Article 20 June 2024

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Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention

Sophie J. Hopkin
Poppy Nathan
Myriam Chimen
Brief CommunicationOpen Access18 Jul 2024
Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice

Sanne J. M. Stefens
Nicole van Vliet
Ingrid van der Pluijm
ArticleOpen Access20 Jun 2024
Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer’s disease rat model as a measure of early network alterations

Saba Amiri
Monica van den Berg
Georgios A. Keliris
ArticleOpen Access20 Jun 2024
Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study

Christopher E. Zwilling
Jisheng Wu
Aron K. Barbey
ArticleOpen Access21 May 2024

Announcements

Call for papers on Cancer and aging

This cross-journal Collection invites original research that explicitly explores the role of aging in cancer and vice versa, from the bench to the bedside.
CfP - Generative AI for aging research & drug discovery

Call for papers on Generative AI for aging research and drug discovery. This Collection invites multidisciplinary groups to submit their research in Generative Artificial Intelligence for aging research and drug discovery.
Call for Papers - Reproductive Aging

This collection invites research addressing the molecular basis of reproductive aging, specifically on delaying reproductive declines and curtailing adverse health consequences.

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Browse articles

Vegetarian diet and healthy aging among Chinese older adults: a prospective study

Guliyeerke Jigeer
Kaiyue Wang
Xiang Gao
ArticleOpen Access01 Apr 2025
Ovarian vascular aging: a hidden driver of mid-age female fertility decline

Although ovarian reserve remains sufficient, ovarian function declines in mid-age, leading to reduced fertility around age 35, with the causes remaining unclear. Recent studies highlight vascular aging as a key factor in this decline, with age-related reductions in ovarian vascular remodeling disrupting oocyte development. Salidroside, a natural compound that reverses ovarian vascular aging and promotes ovarian angiogenesis, presents a promising strategy to rejuvenate ovarian health and enhance fertility, offering potential for preserving reproductive function in aged women.

Ge Wang
Ruobing Yang
Hua Zhang
CommentOpen Access30 Mar 2025
Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila

Suresh Poudel
Chia-Lung Chuang
Fabio Demontis
ArticleOpen Access30 Mar 2025
Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil)

Felipe Mendes Delpino
Alexandre Dias Porto Chiavegatto Filho
Bruno Pereira Nunes
ArticleOpen Access28 Mar 2025
Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice

Hyejin Shin
Haeseung Lee
Sooseong You
ArticleOpen Access26 Mar 2025
Optimizing metabolic health with digital twins

Chengxun Su
Peter Wang
Dean Ho
PerspectiveOpen Access24 Mar 2025
Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer’s disease

Ellen Walter
Gabrielle Angst
Chenran Wang
ArticleOpen Access16 Mar 2025
The role of inhibitory and excitatory neurometabolites in age-related differences in action selection

Geraldine Rodríguez-Nieto
Amirhossein Rasooli
Stephan P. Swinnen
ArticleOpen Access13 Mar 2025
Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance

Gesa Poetzsch
Luca Jelacic
Thomas Hankeln
ArticleOpen Access06 Mar 2025

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Research Associate

We are seeking an experienced and motivated Research Associate to join our dynamic research team in the Douglas Lab!

Dallas, Texas (US)

UT Southwestern Medical Center - Douglas Laboratory
Faculty positions available at International Center for Aging and Cancer, Haikou, China

Senior PI&Junior PI,Aiming at the cutting-edge scientific problems and/or core technologies、original scientific problems and/or key technologies.

Haikou, Hainan (CN)

International Center for Aging and Cancer, ICAC
Faculty Positions, Aging and Neurodegeneration, Westlake Laboratory of Life Sciences and Biomedicine

Applicants with expertise in aging and neurodegeneration and related areas are particularly encouraged to apply.

Hangzhou, Zhejiang, China

Westlake Laboratory of Life Sciences and Biomedicine (WLLSB)
Open PI Positions at SMART

Shenzhen, Guangdong (CN)

Shenzhen Medical Academy of Research and Translation
Talent Recruitment of Post-Doctoral Fellow, SMART

Shenzhen, Guangdong (CN)

Shenzhen Medical Academy of Research and Translation

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns

Featured

Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention

Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice

Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer’s disease rat model as a measure of early network alterations

Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study

Announcements

Call for papers on Cancer and aging

CfP - Generative AI for aging research & drug discovery

Call for Papers - Reproductive Aging

Browse articles

Vegetarian diet and healthy aging among Chinese older adults: a prospective study

Ovarian vascular aging: a hidden driver of mid-age female fertility decline

Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila

Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil)

Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice

Optimizing metabolic health with digital twins

Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer’s disease

The role of inhibitory and excitatory neurometabolites in age-related differences in action selection

Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance

Trending - Altmetric

Science jobs

Research Associate

Faculty positions available at International Center for Aging and Cancer, Haikou, China

Faculty Positions, Aging and Neurodegeneration, Westlake Laboratory of Life Sciences and Biomedicine

Open PI Positions at SMART

Talent Recruitment of Post-Doctoral Fellow, SMART

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Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study

Vegetarian diet and healthy aging among Chinese older adults: a prospective study

A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging

Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila

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