Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

EHRs could clarify drug safety in pregnant people

Nature Medicine volume 26, pages 820–821 (2020)Cite this article

Subjects

Testing drug safety in people who are pregnant remains a wicked problem, but in the transition toward big data and machine learning, target trials could afford a viable alternative to randomized, controlled trials.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Schachter, A. D. & Kohane, I. S. Reprod. Toxicol. 31, 562–569 (2011).

    Article  CAS  Google Scholar 

  2. van der Graaf, R. et al. Trials 19, 78 (2018).

    Article  Google Scholar 

  3. Labrecque, J. A. & Swanson, S. A. Eur. J. Epidemiol. 32, 473–475 (2017).

    Article  Google Scholar 

  4. Goldstein, J. A., Bastarache, L. A., Denny, J. C., Pulley, J. M. & Aronoff, D. M. Am. J. Reprod. Immunol. 80, e12971 (2018).

    Article  Google Scholar 

  5. Jerome, R. N. et al. Drug Saf. 41, 303–311 (2018).

    Article  CAS  Google Scholar 

  6. Challa, A. P. et al. bioRxiv https://doi.org/10.1101/860627 (2019).

    Article  Google Scholar 

  7. Vernetti, L. et al. Sci. Rep. 7, 1–15 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

We thank A. L. Beam for insights on target trials.

Author information

Authors and Affiliations

  1. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA

    Anup P. Challa, Robert R. Lavieri & Jill M. Pulley

  2. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA

    Anup P. Challa & Ethan S. Lippmann

  3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Jeffery A. Goldstein

  4. Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA

    Lisa Bastarache

  5. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

  6. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

  7. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    David M. Aronoff

Authors
  1. Anup P. Challa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert R. Lavieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ethan S. Lippmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jeffery A. Goldstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lisa Bastarache
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jill M. Pulley
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. David M. Aronoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

A.P.C., R.R.L., E.S.L., J.A.G. and L.B. drafted this Comment, and J.M.P. and D.M.A. reviewed it for completeness and technical accuracy.

Corresponding author

Correspondence to Anup P. Challa.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Challa, A.P., Lavieri, R.R., Lippmann, E.S. et al. EHRs could clarify drug safety in pregnant people. Nat Med 26, 820–821 (2020). https://doi.org/10.1038/s41591-020-0925-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-020-0925-1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research