Interfacial investigations
Studying complex problems with a probe is a good start, but using multiple probes is better. As such, knowing what techniques can be used simultaneously, correlatively, or are incompatible is crucial.
Studying complex problems with a probe is a good start, but using multiple probes is better. As such, knowing what techniques can be used simultaneously, correlatively, or are incompatible is crucial.
Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs can have both broad or specific lysine targeting whereas peptide- and protein-based TCIs were shown to provide high target specificity for lysines in shallow protein surfaces.